Avance Nerve Graft

Avance Nerve Graft is an off-the-shelf processed human nerve allograft intended for the surgical repair of peripheral nerve discontinuities. Through a proprietary cleansing process for recovered human peripheral nerve tissue, the graft preserves the essential inherent structure of the ECM while cleansing away cellular and noncellular debris.

Avance Nerve Graft provides the following key advantages:

  • Three-dimensional scaffold for bridging a nerve gap
  • Decellularized and cleansed extracellular matrix that remodels into patient’s own tissue
  • No donor nerve surgery, therefore no comorbidities associated with an additional surgical site
  • Available in a variety of lengths and diameters to meet a range of gap lengths and anatomical needs
  • Supplied sterile with three years shelf life (kept frozen at or below -40º C/F)

regulatory classification

Avance Nerve Graft is a human tissue for transplantation. Avance Nerve Graft is processed and distributed in accordance with U.S. FDA requirements for human cellular and tissue-based products (HCT/P) under 21 CFR Part 1271 regulations, U.S. State regulations and the guidelines of the American Association of Tissue Banks (AATB). Additionally, international regulations are followed as appropriate.

This graft is to be dispensed only by or on the order of a licensed physician.

indications for use

Avance Nerve Graft is a processed nerve allograft (human) intended for the surgical repair of peripheral nerve discontinuities to support regeneration across the defect.


Avance Nerve Graft is contraindicated for use in any patient whose soft tissue implants are contraindicated. This includes any pathology that would limit the blood supply and compromise healing or evidence of a current infection.


Careful donor screening, laboratory testing, tissue processing and gamma irradiation have been used to minimize the risk of transmission of relevant communicable diseases to the patient. As with any processed human donor tissue, Avance cannot be guaranteed to be free of all pathogens. Do not reuse or re-sterilize Avance Nerve Graft and do not refreeze product if thawed.

Jeffrey’s story

Jeffrey suffered severe damage to his left ulnar nerve when struck by gunfire while serving in Afghanistan. His ulnar nerve was repaired using Avance Nerve Graft and Axoguard Nerve Protector. Jeffrey is now a medically retired U.S. Marine happily working as a park ranger.

See story