Avance^® is allograft tissue for bridging nerve discontinuities. Avance^® a decellularized and cleansed extracellular matrix from donated human peripheral nerve. The cleaning process preserves the inherent and relevant structural characteristics of the tissue. Avance® simply connects the proximal and distal ends of a transected nerve. Regenerating axons can grow through the allograft scaffold, into the patient’s distal nerve tissue toward the target muscle or skin.

Similar to nerve autografts, Avance^® provides the surgeon with desired handling and structural characteristics: pliability of soft tissue, an intact epineurium to suture the graft in place, and intact endoneurial tubes for the axons to grow through. Avance® is supplied sterile in a variety of lengths and diameters.

REGULATORY CLASSIFICATION
Avance^® is a human tissue for transplantation. It is processed and distributed in accordance with FDA for Human Cellular and Tissue-based Products (21 CFR Part 1271), State regulations and the guidelines of the American Association of Tissue Banks (AATB). This graft is to be dispensed only by, or on the order of, a licensed physician.

APPLICATIONS FOR USE
Avance^® is allograft tissue for bridging peripheral nerve discontinuities.

CONTRAINDICATIONS
Avance^® is contraindicated for use in any patient in whom soft tissue implants are contraindicated. This includes any pathology that would limit the blood supply and compromise healing or evidence of a current infection.

WARNINGS
Careful donor screening, laboratory testing, tissue processing, and gamma irradiation have been utilized to minimize the risk of transmission of relevant communicable diseases to the patient. As with any processed human donor tissue, Avance^® cannot be guaranteed to be free of all pathogens.
Do NOT reuse or re-sterilize.
Do NOT refreeze product if thawed.