AxoGuard® Nerve Connector is a coaptation aid allowing for close approximation of severed nerves. With AxoGuard® Nerve Connector, the nerve stumps can be aligned and entubulated. AxoGuard® Nerve Connector is provided sterile, for single use only, and in a variety of sizes to meet the surgeon’s needs.
 AxoGuard® Nerve Connector can be used to:
- Bridge gaps up to 5mm
- Aid coaptation in direct repair, grafting, or cable grafting
- Reinforce the coaptation site
AxoGuard® Nerve Connector has the following advantages:
- Unique 10 mm length for reliable results1
- Alleviates tension at the repair site2
- Reduces fibrosis at repair site by reducing number of required sutures (versus direct repair)3
 Reduces potential for fascicular mismatch4,5,6- Reduces the risk of neuroma7,8,9,10
- Semi-translucence allows visualization of underlying nerve
- Strong and flexible, plus easy to suture
AxoGuard® is comprised of a 3-dimensional extracellular matrix that supports regeneration and healing. It works with the body’s natural healing process to:
- Repair. Isolates and protects the nerve during the healing process.10
- Remodel. Gradually incorporated with patient’s own cells to form a tissue similar to the nerve’s
epineurium.10, 11, 12, 13
- Revascularize. Encourages capillary ingrowth to bring vascularity to the repair site.10,11,13
- Resistant to Infection. Able to be used in a contaminated field. Revascularization allows the body’s defense mechanisms to reach and respond to infection.14, 15, 16
References:
1. Weber, et al. 2000, Plast Reconstr Surg 106(5):1036-1048.
2. Schmidhammer, et al. 2004, J Trauma 56(3):571-584.
3. Millesi, et al. 1972, J Bone Joint Surg Am 54(4): 727-750.
4. Evans, et al. 1991, Brain Res 559(2):315-321.
5. Hasegawa, et al. 1996, J Hand Surg [Am] 21(2):259-265.
6. Zhang, et al. 2009, Artif Cells Blood Substit Immobil Biotechnol 37 (2):101-104.
7. Danielsson, et al. 1996, Exp Neurol 139(2):238-243.
8. Malizos, et al. 1997, Am J Orthop 26(7):481-485.
9. Tyner, et al. 2007, Am J Surg 193(1):e1-6.
10. Data on file at AxoGen, Inc.
11. Badylak, et al. 1998, J Biomater Sci Polym Ed 9(8):863-878.
12. Hodde, et al. 2007, J Mater Sci Mater Med 18(4):545-550.
13. Nihsen, et al. 2008, Adv Skin Wound Care 21(10):479-486.
14. Franklin, et al. 2004, Hernia 8(3):186-189.
15. Jernigan, et al. 2004, Ann Surg 239(5):733-740.
16. Shell, et al. 2005, Ann Surg 241(6):995-1004. |
